Armodafinil is the parent drug of Artvigil. More and more people around the world work the night shift. In the US, as many as 18% of people work the night shift, and similar numbers can be found in other parts of Europe, Australia, the Middle East, and Asia. Shift work includes any work shift from 7 a.m. to 6 a.m., such as evening, night, or early morning, and changing shifts that force workers to change their sleep schedules and have an effect on their sleep habits.
Shape of Shift Work
It is thought that night shifts are some of the hardest shifts to work, and they are bad for people’s health in many ways. Night shift workers usually get two to four hours less sleep than evening or changing shift workers. This is because they have to sleep during the normal rising part of the circadian rhythm, which makes them awake for longer. Lighting and noises make it harder for them, and they end up in Stage 2 Rapid Eye Movement Sleep, which is the least restful stage of sleep.
There is a bigger problem in the early morning or during the second half of the shift, which makes work more stressful and raises the risk of mistakes and accidents. Psychiatric effects have been seen in the form of nervousness, anger, and anxiety, which can affect the whole body’s health and cause digestive problems and metabolic diseases such as type II diabetes and heart problems.
The problem is called shift work sleep disorder, which is a broad term for all the problems that come up because of shift work. Though there are other treatments available, psychostimulants like Armodafinil and Artvigil are thought to be some of the best. It has been shown that Artvigil 150mg can help people with more severe chronic shift work disorders feel less sleepy during the day. It also improves long-term memory and attention that are affected by not getting enough sleep or having changes in your circadian cycle.
Something about vigil
Armodafinil is a psychostimulant that the FDA has approved to help with issues with being too sleepy during the day. Armodafinil is the enantiopure form of Modafinil, which is also a very strong drug. It has a longer half-life and better absorption because it is racemic-pure. Armodafinil’s generic version is called Artvigil, and it is made by HAB Pharmaceuticals in India. It has the same pharmacodynamics, qualities, and other features. It works especially well for people who work the night shift because it keeps them awake and alert by reuptaking dopamine.
Artvigil vs. Modafinil for People with Shift Work Sleep Disorder
A 12-week, double-blind study with 211 people with SWSD (Shift Work Sleep Disorder) was done to compare how well and safely Armodafinil (the main ingredient in Artvigil) worked. The subjects were given either 150 mg of Armodafinil or Modalert 200 an hour before their shift. Researchers used their sleepiness scores to assess how well the medication was working.
Armodafinil worked better than Modafinil in SWSD situations and was safer overall. In different people, modafinil worked in different ways, and the amount went from 200 mg to 600 mg for long-term cases. But Armodafinil had a steady strength profile, and the 200 mg strength stayed awake throughout the shift with the same result. As long as the dose was given every 7 to 11 hours, the plasma concentration was 43% higher than with Modafinil. Over 24 hours, there was 28% less change than with Modafinil.
How exactly does Artvigil work to help people with shiftwork sleep disorders?
To better understand Artvigil’s healing benefits, it is important to know how working the night shift affects the CNS and PNS biologically. Changing the time of day affects the circadian rhythms of living things and changes how the suprachiasmatic nucleus (SCN) in our brains works.
The SCN is a structure on both sides of the hypothalamus that is in the front part. It controls when you sleep and wake up and makes sure that it works with circadian rhythms in other parts of the brain and tissues to help you change your behavior. Some of the other things that SCN controls are core body temperatures, hormonal systems, memory, psychomotor processes, and behavioral ones.
The light-dark cycle is one example of how its environment controls it. People who work the night shift have a change in their SCN rhythm, which makes them sleepy, unable to sleep, less productive at work, less able to think clearly, and tired.